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  • 201.
    Boström, Anita
    et al.
    Institutionen för hälsovetenskaper, Karlstads universitet, Sverige.
    Lindmark, Ulrika
    Jönköping University, HHJ, Avd. för naturvetenskap och biomedicin, Sverige.
    Ludvigsson, Mikael
    Linköpings universitet, Institutionen för biomedicinska och kliniska vetenskaper, Centrum för social och affektiv neurovetenskap. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Psykiatricentrum, Psykiatriska kliniken i Linköping. Region Östergötland, Närsjukvården i centrala Östergötland, Medicinska och geriatriska akutkliniken. Linköpings universitet, Institutionen för hälsa, medicin och vård, Avdelningen för prevention, rehabilitering och nära vård.
    Saveman, Britt-Inger
    Institutionen för omvårdnad, Umeå universitet, Sverige.
    Simmons, Johanna
    Linköpings universitet, Institutionen för hälsa, medicin och vård, Avdelningen för prevention, rehabilitering och nära vård. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Närsjukvården i centrala Östergötland, Medicinska och geriatriska akutkliniken.
    Siverskog, Anna
    Jönköping University, HHJ, Avd. för socialt arbete, Sverige.
    Åkerlund, Nina
    Jönköping University, HHJ, Avd. för socialt arbete, Sverige.
    Förekomsten av våld i nära relationer bland äldre personer2022Ingår i: Äldre personers utsatthet för våld i nära relationer: Interprofessionella perspektiv / [ed] Lena Östlund, Lund: Studentlitteratur AB , 2022, s. 31-64Kapitel i bok, del av antologi (Övrigt vetenskapligt)
  • 202.
    Boström, Martina
    Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa.
    Trygghet - på vems villkor? Uppfattningar om och erfarenheter av trygghet hos äldre personer med behov av omsorg2014Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
    Abstract [sv]

    Syftet med avhandlingen var att bidra till ökad förståelse av hur äldre personer med skiftande omsorgsbehov uppfattade och erfor trygghet, i ordinärt och särskilt boende.

    Avhandlingens två första studier baserades på material från fokusgruppintervjuer med totalt 45 äldre personer boende i seniorboende. Intervjuerna analyserades med kvalitativ innehållsanalys (I, II). Den tredje studien bestod av en sekundäranalys av en brukarenkät till 350 äldre personer i ordinärt boende med hemtjänst och 145 äldre personer i särskilt boende. Materialet bearbetades med deskriptiv och analytisk statistik (III). I den fjärde studien följdes tre äldre personer, genom djupintervjuer och observationer under 12-16 veckor, vid flytt till särskilt boende och den första tiden på särskilt boende. Även detta material analyserades med kvalitativ innehållsanalys (IV).

    Avhandlingens resultat visar bland annat att de trygghetslarm som de äldre hade erfarenhet av uppfattades som begränsande då larmets korta räckvidd gav orsak till minskad frihet, otrygghet, oro och rädsla (I). Övervakningsteknik, där den äldres person och position övervakas i större omfattning, ansågs inte som något problem att använda när omsorgsinsatserna ökade, så länge detta medförde ökad trygghet (II). Upplevd hälsa, relationstrygghet samt kunskap och kontroll var faktorer som var positivt relaterade till hur äldre personer med äldreomsorg uppfattade och erfor trygghet i vardagen, både i ordinärt och i särskilt boende (III). Flytt till särskilt boende som innebar att stegvis överlämna sitt livoch sin kontroll till omsorgspersonalen, ledde till en känsla av ökad säkerhet för de äldre personerna men inte nödvändigtvis till känsla av trygghet (IV).

    Resultatet tolkades i förhållande till Antonovskys salutogena teori där de tre koncepten meningsfullhet, hanterbarhet och begriplighet, tillsammans utgör grunden för känsla av sammanhang (KASAM).

    Sammanfattningsvis uppfattade och erfor äldre personer trygghet som så meningsfull att de kunde tänka sig att ge avkall på en del av sin frihet, integritet, självständighet och självbevarande för att uppnå den. De äldre personerna beskrev att resurser som personal och trygghetslarm stärkte tryggheten, men att hanterbarheten av dessa resurser kan stärkas ytterligare, i både ordinärt boende och särskilt boende. Resultaten visaratt äldre personers begriplighet av vardagen relaterar positivt till uppfattningar och erfarenheter av trygghet. Äldre personer saknar dock begriplighet avseende exempelvis trygghetslarm och nya rutiner, vilket får negativ inverkan på deras trygghet. Äldre personer bör ges större utrymme att själva beskriva trygghet utifrån sina unika villkor. För att stärka trygghet på äldre personers villkor, oavsett deras omsorgsbehov, bör således hanterbarheten, men framförallt begripligheten, stärkas.

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  • 203.
    Bouillon, Kim
    et al.
    Department of Epidemiology and Public Health, University College London, London, UK.
    Kivimäki, Mika
    Department of Epidemiology and Public Health, University College London, London, UK.
    Hamer, Mark
    Department of Epidemiology and Public Health, University College London, London, UK.
    Sabia, Severine
    Department of Epidemiology and Public Health, University College London, London, UK.
    Fransson, Eleonor
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för naturvetenskap och biomedicin. Högskolan i Jönköping, Hälsohögskolan, HHJ. Åldrande - livsvillkor och hälsa. Högskolan i Jönköping, Hälsohögskolan, HHJ. ADULT.
    Singh-Manoux, Archana
    Department of Epidemiology and Public Health, University College London, London, UK.
    Gale, Catharine R.
    MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
    Batty, G. David
    Department of Epidemiology and Public Health, University College London, London, UK.
    Measures of frailty in population-based studies: An overview2013Ingår i: BMC Geriatrics, ISSN 1471-2318, E-ISSN 1471-2318, Vol. 13, nr 64Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Although research productivity in the field of frailty has risen exponentially in recent years, there remains a lack of consensus regarding the measurement of this syndrome. This overview offers three services: first, we provide a comprehensive catalogue of current frailty measures; second, we evaluate their reliability and validity; third, we report on their popularity of use.

    Methods: In order to identify relevant publications, we searched MEDLINE (from its inception in 1948 to May 2011); scrutinized the reference sections of the retrieved articles; and consulted our own files. An indicator of the frequency of use of each frailty instrument was based on the number of times it had been utilized by investigators other than the originators.

    Results: Of the initially retrieved 2,166 papers, 27 original articles described separate frailty scales. The number (range: 1 to 38) and type of items (range of domains: physical functioning, disability, disease, sensory impairment, cognition, nutrition, mood, and social support) included in the frailty instruments varied widely. Reliability and validity had been examined in only 26% (7/27) of the instruments. The predictive validity of these scales for mortality varied: for instance, hazard ratios/odds ratios (95% confidence interval) for mortality risk for frail relative to non-frail people ranged from 1.21 (0.78; 1.87) to 6.03 (3.00; 12.08) for the Phenotype of Frailty and 1.57 (1.41; 1.74) to 10.53 (7.06; 15.70) for the Frailty Index. Among the 150 papers which we found to have used at least one of the 27 frailty instruments, 69% (n = 104) reported on the Phenotype of Frailty, 12% (n = 18) on the Frailty Index, and 19% (n = 28) on one of the remaining 25 instruments.

    Conclusions: Although there are numerous frailty scales currently in use, reliability and validity have rarely been examined. The most evaluated and frequently used measure is the Phenotype of Frailty.

  • 204.
    Boussard, Annika
    et al.
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen.
    Amcoff, Mirjam
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen.
    Buechel, Séverine D.
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen.
    Kotrschal, Alexander
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen. Wageningen University & Research, Netherlands.
    Kolm, Niclas
    Stockholms universitet, Naturvetenskapliga fakulteten, Zoologiska institutionen.
    The link between relative brain size and cognitive ageing in female guppies (Poecilia reticulata) artificially selected for variation in brain size2021Ingår i: Experimental Gerontology, ISSN 0531-5565, E-ISSN 1873-6815, Vol. 146, artikel-id 111218Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Cognitive ageing is the general process when certain mental skills gradually deteriorate with age. Across species, there is a pattern of a slower brain structure degradation rate in large-brained species. Hence, having a larger brain might buffer the impact of cognitive ageing and positively affect survival at older age. However, few studies have investigated the link between relative brain size and cognitive ageing at the intraspecific level. In particular, experimental data on how brain size affects brain function also into higher age is largely missing. We used 288 female guppies (Poecilia reticulata), artificially selected for large and small relative brain size, to investigate variation in colour discrimination and behavioural flexibility, at 4-6, 12 and 24 months of age. These ages are particularly interesting since they cover the life span from sexual maturation until maximal life length under natural conditions. We found no evidence for a slower cognitive ageing rate in large-brained females in neither initial colour discrimination nor reversal learning. Behavioural flexibility was predicted by large relative brain size in the youngest group, but the effect of brain size disappeared with increasing age. This result suggests that cognitive ageing rate is faster in large-brained female guppies, potentially due to the faster ageing and shorter lifespan in the large-brained selection lines. It also means that cognition levels align across different brain sizes with older age. We conclude that there are cognitive consequences of ageing that vary with relative brain size in advanced learning abilities, whereas fundamental aspects of learning can be maintained throughout the ecologically relevant life span.

  • 205.
    Bouwmeester Stjernetun, Björn
    et al.
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering. School of Health and Welfare, Jönköping University, Sweden.
    Gillsjö, Catharina
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering. College of Nursing, University of Rhode Island, Kingston, RI, USA.
    Odzakovic, Elzana
    School of Health and Welfare, Jönköping University, Sweden.
    Hallgren, Jenny
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering.
    ”It´s like walking in a bubble”, nursing students´ perspectives on age suit simulation in a home environment – group interviews from reflection seminars2024Ingår i: BMC Nursing, E-ISSN 1472-6955, Vol. 23, nr 1, artikel-id 124Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background

    Older persons with age-related and complex health problems will increasingly depend on care provision from nurses in their own homes. However, a barrier to quality care is ageism and nursing students´ disinterest in geriatrics. In addition, nurse education often falls short in preparing students for the complexity of geriatric care. Welfare technology (WT) is progressively implemented in home care to help older persons live at home despite their health problems. However, this process is intricate and requires acceptance and digital literacy among caregivers and older persons. Despite these challenges, nurse education can address and change negative attitudes through innovative teaching methods such as age suit simulation. Therefore, the study aims to describe nursing students´ experiences of age suit simulation in a home-like environment with WT and technical aids, and will reveal their perspective on ageing and providing care to older adults.

    Methods

    A qualitative explorative design using semi-structured group interviews (n=39) among nursing students. Data was analysed through reflexive thematic analysis.

    Results

    The analysis generated three main themes; “It’s like walking in a bubble”, “An eye opener” and “Concerns about ageing and the current structure of geriatric care”. The main themes included eight subthemes. Adapting to the sensory and physical limitations of the age suit was an immersive experience and caused feelings of frustration, loneliness and disconnection. A prominent result was a raised awareness of cognitive loss, especially impaired vision, and students felt the simulations had made them aware of the everyday challenges older persons faced. Students highlighted the importance of patience and giving enough time in care situations by being present and having a critical perspective of WT. The students were mostly negative towards their own ageing and could better relate to older persons´ vulnerability.

    Conclusions

    Age suit simulation was described as an embodied and eye-opening experience, raising nursing students´ awareness of older persons´ functional limitations and the consequences for dignity and independence. Coping with cognitive loss was especially difficult. Students were motivated to apply their new knowledge to clinical practice. Age suit simulation can complement geriatric education, preparing students for the complex care needs of older persons.

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  • 206.
    Bouwmeester Stjernetun, Björn
    et al.
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering. School of Health and Welfare, Jönköping University, Sweden.
    Hallgren, Jenny
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering. School of Health and Education, University of Skövde, Skövde, Sweden.
    Gillsjö, Catharina
    Högskolan i Skövde, Institutionen för hälsovetenskaper. Högskolan i Skövde, Forskningsmiljön hälsa, hållbarhet och digitalisering. College of Nursing, University of Rhode Island, Kingston, Rhode Island, USA.
    Effects of an age suit simulation on nursing students’ perspectives on providing care to older persons - an education intervention study2024Ingår i: Educational gerontology, ISSN 0360-1277, E-ISSN 1521-0472, Vol. 50, nr 3, s. 240-253Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Nursing students are important future health care providers to the growing number of older persons in society. However, two barriers are their common ageist attitudes and lack of interest in geriatrics. This is a concern in light of the global demand for nurses and a challenge that need to be addressed in nurse education. Age suit simulation has been shown to affect the attitudes of students toward older persons, but the important context of home is often missing from studies. Accordingly, the present study employed a quantitative approach with the goal of investigating the effects of aging simulation with an age suit in a home context as a part of experiential learning among second-year nursing students. The age simulation allowed the students to experience both specific and common health problems from the patient’s point of view in a controlled environment and a relevant context: the home. Data were collected using a questionnaire in a quasi-experimental pretest – posttest design with a control group. Results showed that the intervention had a positive effect on various aspects of the nursing students’ perspectives on caring for older persons. Work experience was associated with more positive attitudes. The control group was more negative toward geriatrics as a career choice than the intervention group. In conclusion, age suit simulation can be an innovative part of nurse education because it raises awareness and understanding of the health challenges of older persons, which are important in combating ageism among future nurses.

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  • 207.
    Bratt, Anna S.
    Linnéuniversitetet, Fakulteten för Hälso- och livsvetenskap (FHL), Institutionen för psykologi (PSY).
    Does Perceived Ageism Affect the Health and Life Satisfaction of Older Swedish Adults?2019Konferensbidrag (Refereegranskat)
    Abstract [en]

    BACKGROUND

    Ageism can have negative repercussions on older adults’ health and well-being. Ageism, in contrast to racism and sexism, is an understudied topic in research. Selfcompassion, the ability to take care of and support oneself in moments of suffering, is hypothesized to buffer the negative effects of ageism on older adults.

    Aims:

    Perceived ageism, i.e., individuals’ experience of attitudes towards older adults in society, and the association to life satisfaction (LS), health-related quality of life (HRQoL), feelings of unsafety and self-compassion was investigated.

    Sample

    A sample of 698 randomly selected participants aged 66–102 years from the Blekinge region of the Swedish National Study on Ageing and Care (SNAC-B) participated. Survey data were collected in 2013/2015.

    RESULTS

    The group who experienced positive ageism in society had higher LS than those who experienced negative or neutral ageism. Those experiencing negative ageism had significantly lower HRQoL and higher feelings of unsafety than those who experience positive ageism. 

    No differences between the three groups were found for self-compassion.However, correlation analysis revealed that higher self-compassion was associated with less feelings of unsafety, less loneliness, and better physical and mental health.

    Discussion

    The reason for more negative health outcomes for those experiencing negative ageism is not known. A possible explanation is that those with mental and physical problems experience more negative attitudes towards themselves and other older adults. Older adults are described as being less wellserved by both mental and physical health services than younger populations. Positive ageism was associated with higher self-compassion, which could be a sign that the more accepting you are towards yourself, the more accepting you perceive the attitudes towards older adults in society.

  • 208.
    Bravell, Marie Ernsth
    et al.
    Institute of Gerontology, School of Health and Welfare, Jönköping University, Sweden.
    Finkel, Deborah
    Department of Psychology, Indiana University Southeast, USA.
    Dahl Aslan, Anna K.
    Institute of Gerontology, School of Health and Welfare, Jönköping University, Sweden ; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Reynolds, Chandra A.
    Department of Psychology, University of California, Riverside, USA.
    Hallgren, Jenny
    Institute of Gerontology, School of Health and Welfare, Jönköping University, Sweden.
    Pedersen, Nancy L.
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden ; Department of Psychology, University of Southern California, Los Angeles, USA.
    Motor functioning differentially predicts mortality in men and women2017Ingår i: Archives of gerontology and geriatrics (Print), ISSN 0167-4943, E-ISSN 1872-6976, Vol. 72, s. 6-11Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Introduction

    Research indicates gender differences in functional performance at advanced ages, but little is known about their impact on longevity for men and women.

    Objective

    To derive a set of motor function factors from a battery of functional performance measures and examine their associations with mortality, incorporating possible gender interactions.

    Method

    Analyses were performed on the longitudinal Swedish Adoption/Twin Study of Aging (SATSA) including twenty-four assessments of motor function up to six times over a 19-year period. Three motor factors were derived from several factor analyses; fine motor, balance/upper strength, and flexibility. A latent growth curve model was used to capture longitudinal age changes in the motor factors and generated estimates of intercept at age 70 (I), rates of change before (S1) and after age 70 (S2) for each factor. Cox regression models were used to determine how gender in interaction with the motor factors was related to mortality.

    Results

    Females demonstrated lower functional performance in all motor functions relative to men. Cox regression survival analyses demonstrated that both balance/upper strength, and fine motor function were significantly related to mortality. Gender specific analyses revealed that this was true for women only. For men, none of the motor factors were related to mortality.

    Conclusion

    Women demonstrated more difficulties in all functioning facets, and only among women were motor functioning (balance/upper strength and fine motor function) associated with mortality. These results provide evidence for the importance of considering motor functioning, and foremost observed gender differences when planning for individualized treatment and rehabilitation.

  • 209.
    Brink, Satya
    Gerontology Research Centre, Simon Fraser University, Burnaby, Canada.
    Elder care: the nexus for family, work and health policy2004Rapport (Övrigt vetenskapligt)
  • 210.
    Brink, Satya
    Gerontology Research Centre, Simon Fraser University, Vancouver, British Columbia, Canada.
    International policy trends in housing the elderly in developed countries1990Ingår i: Ageing International, ISSN 0163-5158, E-ISSN 1936-606X, Vol. 17, nr 2, s. 13-20Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The proportion of elderly persons in the population is rising in the developed countries. Housing and related social policies are undergoing change to respond to this socio-demographic change within the context of wider changes in policy thinking with respect to housing and aging. International trends in housing policy for elderly people may be discerned despite national variations. The governments of developed countries are beginning to be more engaged in multi-sectoral planning, in decentralization of responsibilities for housing, health and support services and in cost-sharing arrangements for housing and related policies. The quality of life for elderly persons has benefitted through increased opportunities for aging in place in their own homes and through better designed residential facilities. The nineties have been called"the age of age." The aging of the population presents immense challenges to the way human settlements are designed and organized. The responses to the challenge will be determined, nevertheless, more by societal choices than by socio-demographic changes. 

  • 211.
    Brink, Satya
    International Consultant in Education and Human Capital, Chelsea, Canada.
    Learning in later years in the lifelong learning trajectory2017Ingår i: Journal of Intergenerational Relationships, ISSN 1535-0770, E-ISSN 1535-0932, Vol. 15, nr 1, s. 14-25Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    An examination of learning in later life in the context of lifelong learning shows that it is a phase on its own and not simply an extension of adult learning, particularly in the 21st century. It exhibits characteristics unlike earlier phases and has benefits that are more aligned with later life. The changes to the growing share of this demographic in the population has implications for the provision of learning opportunities. The life stage changes that are evolving are shown compared to previous generations. The needs and benefits of late life learning are described in contrast to adult learning and the adaptations for successful lifelong learning are listed based on life span theories and current research. 

  • 212.
    Brink, Satya
    Canada Mortgage and Housing Corporation, Government of Canada, Ottawa, Canada, and Gerontology Research Centre, Simon Fraser University, British Columbia, Burnaby, BC, Canada.
    Social equity or distributive justice? The reliance on mainstream and targeted housing policies to serve the elderly in Canada, the United States, Sweden and France1989Ingår i: Scandinavian Housing and Planning Research, ISSN 0281-5737, Vol. 6, nr 2, s. 103-113Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    This paper examines the application of the principles of social equity and distributive justice in practice by governments under economic and demographic pressures. The housing policies that benefit the elderly are identified in Canada, the United States, Sweden and France and a policy analysis of the mainstream and targeted policies is carried out. The objectives of this paper are to observe the use of mainstream and targeted policies to house the elderly, to examine how elements benefiting the elderly are incorporated into mainstream policies and to identify the object! ves of targeted elements of policies benefiting the elderly. Governments tend to use mainstream policies and also to use various strategies for adding targeted elements to them. Targeted policies for the elderly are used sparingly. In practice, government actions for social equity and distributive justice are limited to ensuring access to a minimum level of welfare and reducing inequalities.

  • 213.
    Britting, Sabine
    et al.
    Friedrich Alexander Univ Erlangen Nurnberg, Inst Biomed Aging IBA, Dept Internal Med Geriatr, Erlangen, Germany..
    Artzi-Medvedik, Rada
    Ben Gurion Univ Negev, Recanati Sch Community Hlth Profess, Dept Nursing, Fac Hlth Sci, Beer Sheva, Israel..
    Fabbietti, Paolo
    Italian Natl Res Ctr Aging IRCCS INRCA, Ancona, Italy.;IRCCS INRCA, Lab Geriatr Pharmacoepidemiol & Biostat, Via S Margherita 5, I-60124 Ancona, Italy..
    Tap, Lisanne
    Erasmus MC, Dept Internal Med, Geriatr Med Sect, Rotterdam, Netherlands..
    Mattace-Raso, Francesco
    Erasmus MC, Dept Internal Med, Geriatr Med Sect, Rotterdam, Netherlands..
    Corsonello, Andrea
    Italian Natl Res Ctr Aging IRCCS INRCA, Ancona, Italy..
    Lattanzio, Fabrizia
    Italian Natl Res Ctr Aging IRCCS INRCA, Ancona, Italy..
    Ärnlöv, Johan
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. Karolinska Inst, Div Family Med, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden.;Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden..
    Carlsson, Axel C
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. Karolinska Inst, Div Family Med, Dept Neurobiol Care Sci & Soc, Stockholm, Sweden..
    Roller-Wirnsberger, Regina
    Med Univ Graz, Dept Internal Med Geriatr, Graz, Austria..
    Wirnsberger, Gerhard
    Med Univ Graz, Dept Internal Med, Div Nephrol, Graz, Austria..
    Kostka, Tomasz
    Med Univ Lodz, Dept Geriatr, Hlth Ageing Res Ctr, Lodz, Poland..
    Guligowska, Agnieszka
    Med Univ Lodz, Dept Geriatr, Hlth Ageing Res Ctr, Lodz, Poland..
    Formiga, Francesc
    Bellvitge Univ Hosp, IDIBELL, Geriatr Unit, Dept Internal Med, Barcelona, Spain..
    Moreno-Gonzalez, Rafael
    Bellvitge Univ Hosp, IDIBELL, Geriatr Unit, Dept Internal Med, Barcelona, Spain..
    Gil, Pedro
    Hosp Clin San Carlos, Geriatr Dept, Martin Lagos S-N, Madrid 28040, Spain..
    Martinez, Sara Lainez
    Hosp Clin San Carlos, Geriatr Dept, Martin Lagos S-N, Madrid 28040, Spain..
    Kob, Robert
    Friedrich Alexander Univ Erlangen Nurnberg, Inst Biomed Aging IBA, Dept Internal Med Geriatr, Erlangen, Germany..
    Melzer, Itshak
    Ben Gurion Univ Negev, Dept Phys Therapy, Recanati Sch Community Hlth Profess, Fac Hlth Sci, Beer Sheva, Israel..
    Freiberger, Ellen
    Friedrich Alexander Univ Erlangen Nurnberg, Inst Biomed Aging IBA, Dept Internal Med Geriatr, Erlangen, Germany..
    Kidney function and other factors and their association with falls updates The screening for CKD among older people across Europe (SCOPE) study2020Ingår i: BMC Geriatrics, ISSN 1471-2318, E-ISSN 1471-2318, Vol. 20, artikel-id 320Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Reduced kidney function has become a major public health concern, especially among older people, as Chronic Kidney Disease (CKD) is associated with increased risk of end stage renal disease and mortality. Falls are a serious negative health outcome in older persons with one third of people aged 65 years experiencing a fall per year and increasing fall rates with increasing age. The impact of CKD on falls in older community-dwelling persons is not well investigated. Additionally, lower urinary tract symptoms (LUTS) may also increase the risk of falls. Therefore, our aim was to investigate the impact of CKD and LUTS on falls as well as on injurious falls. Methods: The SCOPE study is an observational, multinational, multicenter, prospective cohort study involving communitydwelling older persons aged 75 years and more recruited from August 2016 to March 2018 in seven European countries. The main outcomes of the present study were any falls and any injurious falls during the 12 months before enrolment The cross-sectional association of estimated glomerular filtration rate (eGFR) and LUIS with study outcomes was investigated by logistic regression analysis adjusted for baseline characteristics of enrolled subjects. Results: Our series consisted of 2256 SCOPE participants (median age = 795 years, 55.7% female). Of them, 746 participants experienced a fall and 484 reported an injurious fall in the 12 months prior to baseline assessment CKD was not significantly associated with falls (OR = 0.95, 95%CI = 0.79-1.14 for eGFR< 60; OR = 1.02, 95%CI = 0.81-128 for eGFR< 45; OR = 1.08, 95%CI = 0.74-1.57 for eGFR< 30) or injurious falls (OR = 0.91, 95%CI = 0.67-124 for eGFR< 60; OR = 0.93, 95%CI = 0.63-137 for eGFR< 45; OR = 1.19, 95%CI = 0.62-2.29 for eGFR< 30). LUTS were found significantly associated with both falls (OR = 156, 95960 =129-1.89) and injurious falls (OR = 158, 95%0 =1.14-2.19), and such associations were confirmed in all multivariable models. Conclusions: Cross-sectional data suggest that CKD may not be associated with history of falls or injurious falls, whereas LUTS is significantly associated with the outcomes.

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  • 214.
    Bromseth, Janne
    et al.
    Stockholms universitet, Humanistiska fakulteten, Institutionen för etnologi, religionshistoria och genusvetenskap.
    Siverskog, Anna
    LHBTQ-personer och åldrande: nordiska perspektiv2013Samlingsverk (redaktörskap) (Refereegranskat)
    Abstract [sv]

    Lhbtq-personer och åldrande: Nordiska perspektiv samlar kunskap om äldre lhbtq-personers livsvillkor och åldrande utifrån studier som genomförts i Sverige, Danmark, Norge och Finland.Författarna uppmärksammar frågor om vad det innebär att under stora delar av livet behöva smyga med sin sexualitet eller könsidentitet, och vad det i olika tider har inneburit att komma ut med sin sexualitet och könsidentitet. Vilka räknas som familj? Hur är det att som äldre transperson påbörja en utredning för att ändra könsidentitet? Hur är det att som äldre behöva omsorgshjälp men att samtidigt vara rädd för att bli diskriminerad på grund av sin sexualitet eller könsidentitet?

  • 215.
    Brorsson, Anna
    et al.
    Karolinska Inst, Sweden.
    Öhman, Annika
    Linköpings universitet, Institutionen för hälsa, medicin och vård, Avdelningen för prevention, rehabilitering och nära vård. Linköpings universitet, Medicinska fakulteten.
    Lundberg, Stefan
    Royal Inst Technol, Sweden.
    Cutchin, Malcolm P.
    Wayne State Univ, MI 48202 USA.
    Nygard, Louise
    Karolinska Inst, Sweden.
    How accessible are grocery shops for people with dementia? A qualitative study using photo documentation and focus group interviews2020Ingår i: Dementia, ISSN 1471-3012, E-ISSN 1741-2684, Vol. 19, nr 6, s. 1872-1888Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background People with dementia who live in ordinary housing need to perform activities outside the home such as visiting friends, talking walks and doing grocery shopping. This article identifies and examines characteristics that may influence accessibility in the space of a grocery shop as perceived by people with dementia. Methods This is a qualitative study with a grounded theory approach. The data collection was done with two different methods. It started with photo documentation and continued with focus group interviews in combination with photo elicitation. Data from both photo documentation and focus groups were analysed according to a grounded theory approach. Results The categories "illogical arrangement", "overload of products, information and people", "visual illusions" and "intrusive auditory stimuli" showed characteristics in the grocery shop that influenced how accessible and usable the informants experienced a shop to be. Furthermore, personal capacities in relation to the specific characteristics of the grocery shop space had an influence on how accessible and usable the informants experienced the grocery shop to be. Capacities to find, stay focused and concentrated, meet stress, remember, interpret and discriminate sensory impressions through hearing and sight came to the fore as important. Conclusions Characteristics of both the shop and the person need to be taken into account when supporting people with dementia in grocery shopping.

  • 216.
    Brändström, Anders
    et al.
    Umeå universitet, Humanistiska fakulteten, Institutionen för idé- och samhällsstudier.
    Meyer, Anna C.
    Modig, Karin
    Sandström, Glenn
    Umeå universitet, Humanistiska fakulteten, Institutionen för idé- och samhällsstudier. Stockholm University Demography Unit (SUDA), Stockholm University.
    Determinants of home care utilization among the Swedish old: nationwide register-based study2022Ingår i: European Journal of Ageing, ISSN 1613-9372, E-ISSN 1613-9380, Vol. 19, s. 651-662Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Since the 1990s, Sweden has implemented aging-in-place policies increasing the share of older adults dependent on home care instead of residing in care homes. At the same time previous research has highlighted that individuals receive home care at a higher age than before. Consequently, services are provided for a shorter time before death, increasing reliance on family and kin as caregivers. Previous studies addressing how homecare is distributed rely primarily on small surveys and are often limited to specific regions. This study aims to ascertain how home care services are distributed regarding individual-level factors such as health status, living arrangements, availability of family, education, and socioeconomic position. To provide estimates that can be generalized to Sweden as a whole, we use register data for the entire Swedish population aged 65 + in 2016. The study's main findings are that home care recipients and the amount of care received are among the oldest old with severe co morbidities. Receiving home care is slightly more common among women, but only in the highest age groups. Childlessness and socioeconomic factors play a small role in who receives home care or not. Instead, the primary home care recipients are those older adults living alone who lack direct support from family members residing in the same household.

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  • 217.
    Brännström, Jon
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Geriatrik.
    Hamberg, Katarina
    Umeå universitet, Medicinska fakulteten, Institutionen för folkhälsa och klinisk medicin, Allmänmedicin.
    Molander, Lena
    Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Geriatrik.
    Lövheim, Hugo
    Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Geriatrik.
    Gustafson, Yngve
    Umeå universitet, Medicinska fakulteten, Institutionen för samhällsmedicin och rehabilitering, Geriatrik.
    Gender disparities in the pharmacological treatment of cardiovascular disease and diabetes mellitus in the very old: an epidemiological, cross-sectional survey2011Ingår i: Drugs & Aging, ISSN 1170-229X, E-ISSN 1179-1969, Vol. 28, nr 12, s. 993-1005Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: There are many reports of disparities in health and medical care both between women and men and between various age groups. In most cases, men receive better treatment than women and young and middle-aged people are privileged compared with the old and the very old. Cardiovascular morbidity and diabetes mellitus are common, increase with age and are often treated extensively with drugs, many of which are known to have significant adverse effects.

    OBJECTIVE: The aim of the study was to analyse gender differences in the pharmacological treatment of cardiovascular disease and diabetes among very old people.

    METHODS: The study took the form of an epidemiological, cross-sectional survey. A structured interview was administered during one or more home visits, and data were further retrieved from medical charts and interviews with relatives, healthcare staff and other carers. Home-dwelling people as well as people living in institutional care in six municipalities in the county of Västerbotten, Sweden, in 2005-7 were included in the study. Half of all people aged 85 years, all of those aged 90 years and all of those aged ≥95 years living in the selected municipalities were selected for inclusion in the study. In total, 467 people were included in the present analysis. The main study outcome measures were medical diagnoses and drug use.

    RESULTS: In total, women were prescribed a larger number of drugs than men (mean 7.2 vs 5.4, p < 0.001). Multiple logistic regression models adjusted for age and other background variables as well as relevant medical diagnoses (hypertension, heart failure) showed strong associations between female sex and prescriptions of thiazide diuretics (odds ratio [OR] 4.4; 95% CI 1.8, 10.8; p = 0.001), potassium-sparing diuretics (OR 3.5; 95% CI 1.4, 8.7; p = 0.006) and diuretics as a whole (OR 1.8; 95% CI 1.1, 2.9; p = 0.021). A similar model, adjusted for angina pectoris, showed that female sex was associated with prescription of short-acting nitroglycerin (OR 3.7; 95% CI 1.6, 8.9; p = 0.003). However, more men had been offered coronary artery surgery (p = 0.001). Of the participants diagnosed with diabetes, 55% of the women and 85% of the men used oral antihyperglycaemic drugs (p = 0.020), whereas no gender difference was seen in prescriptions of insulin.

    CONCLUSIONS: Significant gender disparities in the prescription of several drugs, such as diuretics, nitroglycerin and oral antihyperglycaemic drugs, were observed in this study of very old people. In most cases, women were prescribed more drugs than men. Men more often had undergone coronary artery surgery. These disparities could only in part be explained by differences in diagnoses and symptoms.

  • 218. Burzynska, Agnieszka Z.
    et al.
    Nagel, Irene E.
    Preuschhof, Claudia
    Gluth, Sebastian
    Bäckman, Lars
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). Max Planck Institute for Human Development, Germany.
    Li, Shu-Chen
    Lindenberger, Ulman
    Heekeren, Hauke R.
    Cortical thickness is linked to executive functioning in adulthood and aging2012Ingår i: Human Brain Mapping, ISSN 1065-9471, E-ISSN 1097-0193, Vol. 33, nr 7, s. 1607-20Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Executive functions that are dependent upon the frontal-parietal network decline considerably during the course of normal aging. To delineate neuroanatomical correlates of age-related executive impairment, we investigated the relation between cortical thickness and executive functioning in 73 younger (20-32 years) and 56 older (60-71 years) healthy adults. Executive functioning was assessed using the Wisconsin Card Sorting Test (WCST). Cortical thickness was measured at each location of the cortical mantle using surface-based segmentation procedures on high-resolution T1-weighted magnetic resonance images. For regions involved in WCST performance, such as the lateral prefrontal and parietal cortices, we found that thicker cortex was related to higher accuracy. Follow-up ROI-based analyses revealed that these associations were stronger in older than in younger adults. Moreover, among older adults, high and low performers differed in cortical thickness within regions generally linked to WCST performance. Our results indicate that the structural cortical correlates of executive functioning largely overlap with previously identified functional patterns. We conclude that structural preservation of relevant brain regions is associated with higher levels of executive performance in old age, and underscore the need to consider the heterogeneity of brain aging in relation to cognitive functioning.

  • 219.
    Bäcklund, Nils
    et al.
    Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
    Brattsand, Göran
    Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.
    Israelsson, Marlen
    Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.
    Ragnarsson, Oskar
    Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Burman, Pia
    Department of Endocrinology, Skåne University Hospital, University of Lund, Malmö, Sweden.
    Edén Engström, Britt
    Department of Medical Sciences, Endocrinology and Mineral Metabolism, Uppsala University, Uppsala, Sweden.
    Høybye, Charlotte
    Department of Molecular Medicine and Surgery, Patient Area Endocrinology and Nephrology, Inflammation and Infection Theme, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
    Berinder, Katarina
    Department of Molecular Medicine and Surgery, Patient Area Endocrinology and Nephrology, Inflammation and Infection Theme, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
    Wahlberg, Jeanette
    Linköpings universitet, Institutionen för hälsa, medicin och vård, Avdelningen för diagnostik och specialistmedicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Medicincentrum, Endokrinmedicinska kliniken.
    Olsson, Tommy
    Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
    Dahlqvist, Per
    Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
    Reference intervals of salivary cortisol and cortisone and their diagnostic accuracy in Cushings syndrome2020Ingår i: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 182, nr 6, s. 569-582Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The challenge of diagnosing Cushings syndrome (CS) calls for high precision biochemical screening. This study aimed to establish robust reference intervals for, and compare the diagnostic accuracy of, salivary cortisol and cortisone in late-night samples and after a low-dose (1 mg) dexamethasone suppression test (DST).

  • 220.
    Bökberg, Christina
    et al.
    Lund University, Lund, Sweden.
    Ahlström, Gerd
    Lund University, Lund, Sweden.
    Karlsson, Staffan
    Högskolan i Halmstad, Akademin för hälsa och välfärd, Centrum för forskning om välfärd, hälsa och idrott (CVHI). Lund University, Lund, Sweden.
    Utilisation of formal and informal care and services at home among persons with dementia: a cross-sectional study2018Ingår i: Scandinavian Journal of Caring Sciences, ISSN 0283-9318, E-ISSN 1471-6712, Vol. 32, nr 2, s. 843-851Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background

    The progression of dementia disease implies increasing needs for both informal and formal care and services but also risk of institutionalisation. To better adjust care and services in the phase preceding institutionalisation it is important to find out whether utilisation of formal and informal care and services is determined by increased needs and by who meets the needs.Aim

    The aim was to compare persons with dementia (65+) with different levels of cognitive impairment, regarding utilisation of formal and informal care and service at home.Methods

    The participants consisted of 177 persons with dementia ≥65 years old and at risk of nursing home admission, divided into groups according to their cognitive function. Structured interviews were conducted based on questionnaires about type and amount of formal and informal care utilised, as well as questions regarding cognitive impairment, dependency in activities of daily living (ADLs) and neuropsychiatric symptoms. To analyse the data, descriptive and comparative statistics were used.Results

    The findings revealed that the group with severe dementia used significantly more help with ADLs and supervision in terms of time (number of hours and days) provided by the informal caregiver, compared with the group with moderate dementia. Utilisation of formal care and services was highest in the group with the most severe cognitive impairments (Standardized Mini-Mental State Examination score of <9). The group with severe dementia were more dependent in ADLs and had more neuropsychiatric symptoms (hallucinations and motor disturbances). They were younger and more often cohabitated with the informal caregiver, compared with the group with moderate dementia.Conclusion

    This study shows that in the phase preceding institutionalisation the ADL and supervision needs due to progression of dementia appear to tend to be met first and foremost by the informal caregivers. © 2017 Nordic College of Caring Science.

  • 221.
    Bölenius, Karin
    et al.
    Umeå universitet, Medicinska fakulteten, Institutionen för omvårdnad.
    Lämås, Kristina
    Umeå universitet, Medicinska fakulteten, Institutionen för omvårdnad.
    Sandman, Per-Olof
    Umeå universitet, Medicinska fakulteten, Institutionen för omvårdnad. Division of Caring Sciences, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet.
    Edvardsson, David
    Umeå universitet, Medicinska fakulteten, Institutionen för omvårdnad. School of Nursing and Midwifery, La Trobe University.
    Effects and meanings of a person-centred and health-promoting intervention in home care services: a study protocol of a non-randomised controlled trial2017Ingår i: BMC Geriatrics, ISSN 1471-2318, E-ISSN 1471-2318, Vol. 17, artikel-id 57Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: The literature indicates that current home care service are largely task oriented with limited focus on the involvement of the older people themselves, and studies show that lack of involvement might reduce older people's quality of life. Person-centred care has been shown to improve the satisfaction with care and quality of life in older people cared for in hospitals and nursing homes, with limited published evidence about the effects and meanings of person-centred interventions in home care services for older people. This study protocol outlines a study aiming to evaluate such effects and meanings of a person-centred and health-promoting intervention in home aged care services. Methods/design: The study will take the form of a non-randomised controlled trial with a before/after approach. It will include 270 older people >65 years receiving home care services, 270 relatives and 65 staff, as well as a matched control group of equal size. All participants will be recruited from a municipality in northern Sweden. The intervention is based on the theoretical concepts of person-centredness and health-promotion, and builds on the four pedagogical phases of: theory apprehension, experimental learning, operationalization, and clinical supervision. Outcome assessments will focus on: a) health and quality of life (primary outcomes), thriving and satisfaction with care for older people; b) caregiver strain, informal caregiving engagement and relatives' satisfaction with care: c) job satisfaction and stress of conscience among care staff (secondary outcomes). Evaluation will be conducted by means of self-reported questionnaires and qualitative research interviews. Discussion: Person-centred home care services have the potential to improve the recurrently reported sub-standard experiences of home care services, and the results can point the way to establishing a more person-centred and health-promoting model for home care services for older people.

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  • 222.
    Bülow, Pia H.
    et al.
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för socialt arbete. Högskolan i Jönköping, Hälsohögskolan, HHJ. SALVE (Socialt arbete, Livssammanhang, Välfärd).
    Bülow, Per
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för socialt arbete. Department of Psychiatry, Ryhov County Hospital, Jönköping, Sweden.
    Wilińska, Monika
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för socialt arbete. Högskolan i Jönköping, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping).
    Torgé, Cristina Joy
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Institutet för gerontologi. Högskolan i Jönköping, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping).
    Ernsth-Bravell, Marie
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Institutet för gerontologi. Högskolan i Jönköping, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping).
    Jegermalm, Magnus
    Högskolan i Jönköping, Hälsohögskolan, HHJ, Avd. för socialt arbete. Högskolan i Jönköping, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping).
    The meaning of illness, times and spaces: Stories about severe mental illness from a life course perspective2019Konferensbidrag (Refereegranskat)
  • 223.
    Caballero, Adelaida
    Uppsala universitet, Humanistisk-samhällsvetenskapliga vetenskapsområdet, Historisk-filosofiska fakulteten, Institutionen för kulturantropologi och etnologi.
    Shortchanged: Elderly Women Street Vendors in Malabo, Equatorial Guinea2023Doktorsavhandling, monografi (Övrigt vetenskapligt)
    Abstract [en]

    Normative assumptions regarding reciprocity between adult children and elderly parents continue to dominate narratives on later life in sub-Saharan Africa. Yet strenuous socioeconomic conditions make it difficult for families to meet expectations of care and support. In Malabo, elderly women commonly engage in economic activities such as street vending for survival. Separation from male partners and high unemployment among men and youths often turn senior women into sole providers in multi-generational households. The cultural script of self-sacrificial motherhood, however, leads people to believe that these senior women are hardly entitled to demand reciprocal support – that as proper mothers and grandmothers, they are merely fulfilling a duty. Gender-based forms of exploitation and feelings of desertion characterize family life for many older Equatoguinean women. 

    Elderly women street vendors who live and work in Malabo are also mistreated outside their homes. Harassment, humiliation, and physical invisibilization are some of the means by which ‘patriotic citizens’ and representatives of state authorities protect the government’s narrative of ‘unprecedented development.’

    The thesis explores how elderly women street vendors try to counter the routinized types of violence to which they are exposed and how they strive to assert themselves as persons. I approach the women’s articulations of personhood through the concept of moral economy and discuss them with regard to normative African relationality. The empirical basis of the work is fourteen months of uninterrupted ethnographic field research in Malabo between 2017 and 2018. The analyses rely on social gerontological theories on dependency, intergenerational tensions, prosocial behaviors, gender identity, sexuality, and autonomy, as well as on anthropological theories on the category of the person, everyday violence, morality, gossip, and older women’s sexuality in Africa. The thesis aims to contribute to humanistic gerontological literature by highlighting the meanings that autonomy can take for seniors who live in conditions of no institutional support, normalized violence at home, gender prejudice, and the kind of ageism that arises from narratives that equate social advancement with development, hence identifying old age with anti-values such as ignorance and backwardness. Findings suggest that, among elderly women street vendors in Malabo, striving toward a sense of autonomous personhood is not only a means for coping with the challenges of aging in a difficult socioeconomic milieu, but also a more encompassing rejection of ‘retraditionalized’ national politics and authoritarianism.

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  • 224.
    Cacciani, Nicola
    et al.
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Klinisk neurofysiologi.
    Ogilvie, Hannah
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Klinisk neurofysiologi.
    Larsson, Lars
    Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Klinisk neurofysiologi.
    Age related differences in diaphragm muscle fiber response to mid/long term controlled mechanical ventilation2014Ingår i: Experimental Gerontology, ISSN 0531-5565, E-ISSN 1873-6815, Vol. 59, s. 28-33Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Critically ill intensive care patients are subjected to controlled mechanical ventilation (CMV) which has an important association in triggering the impaired muscle function and the consequent delayed weaning from the respirator. AIM: The main aim of this study was to measure the effects of age and CMV over a period up to 5days on rat diaphragm muscle fibers, more specifically focusing on the changes in fiber structure and function. METHODS: Diaphragm muscle fiber cross-sectional area (CSA) and force generating capacity were measured in young (6months) and old (28-32months) rats in response to five days of CMV. To investigate the biological age of the old rats in this rat strain (F344 BN hybrid), a second set of experiments comparing muscle fiber size and specific force (maximum force normalized to CSA) was investigated in fast- and slow-twitch distal hind limb muscles in 3 different age groups: young adults (6months), middle aged (18months) and old rats (28months). RESULTS: This study shows an unexpected response of the diaphragm fibers to 5days CMV, demonstrating an increased CSA (p<0.001) in both young and old animals. Furthermore, an observed decreased maximum force of 39.8-45.2% (p<0.001) in both young and old animals compared with controls resulted in a dramatic loss of specific force. We suggest that this increase in CSA and decrease in specific force observed in both the young and old diaphragm fibers is an ineffective compensatory hypertrophy in response to the CMV. These results demonstrate an important mechanism of significant importance for the weaning problems associated with mechanical ventilation.

  • 225.
    Cahill, Suzanne
    Jönköping University, Hälsohögskolan, HHJ, Institutet för gerontologi. School of Social Work and Social Policy, Trinity College Dublin, Ireland; Centre for Economic and Social Research on Dementia, National University of Ireland, Galway, Ireland.
    Personhood, dementia literacy, and the causes and consequences of Alzheimer's disease fear2021Ingår i: International psychogeriatrics, ISSN 1041-6102, E-ISSN 1741-203X, Vol. 33, nr 10, s. 997-999Artikel i tidskrift (Övrigt vetenskapligt)
  • 226.
    Cahill, Suzanne
    Jönköping University, Hälsohögskolan, HHJ, Institutet för gerontologi. Trinity College Dublin, Ireland.
    Perspectives on the person with dementia and family caregiving in Ireland2021Bok (Refereegranskat)
    Abstract [en]

    This book is all about dementia in Ireland and what has and has not been happening in a country where dementia has been a taboo topic for so long. In particular it examines the dementia landscape since late 2014, following the launch of Ireland's first National Dementia Strategy. A lot has happened in Ireland since that time but a lot more needs to happen for people to live well with dementia and have their human rights upheld. There are an estimated 55,000 Irish people living with dementia and these figures are set to triple by 2050. Although topics explored in the book,such as obtaining a diagnosis, accessing home care services and moving from home into a nursing home relate to Ireland, they are discussed against the backdrop of policy, practice and research developments in dementia in other parts of the world. In this way the book provides the reader with a wealth of information including research evidence, best practice guidelines and international expertise. The book has been dedicated to Mnánah 'éireann, in recognition of the hard physical and emotional work, caregivers,mostly women do behind closed doors. Throughout the book, an appeal is made for more state support to be given to these formal and informal caregivers. 

  • 227.
    Cahill, Suzanne
    Jönköping University, Hälsohögskolan, HHJ, Institutet för gerontologi. Centre for Economic and Social Research, NUI Galway, Ireland.
    Using technology in dementia care2021Ingår i: Dementia, ISSN 1471-3012, E-ISSN 1741-2684, Vol. 20, nr 8, s. 3055-3056, artikel-id 14713012211011265Artikel, recension (Övrig (populärvetenskap, debatt, mm))
  • 228.
    Cahill, Suzanne
    et al.
    Jönköping University, Hälsohögskolan, HHJ, Institutet för gerontologi. Social Work and Social Policy, Dementia Care NUI Galway, Trinity College Dublin, Dublin, Ireland.
    Bielsten, Therese
    Jönköping University, Hälsohögskolan, HHJ, Institutet för gerontologi.
    Zarit, Steven H.
    Jönköping University, Hälsohögskolan, HHJ, Institutet för gerontologi. Department of Human Development and Family Studies, Penn State University, University Park, PA, USA.
    Developing a Framework for the Support of Informal Caregivers: Experiences from Sweden, Ireland, and the United States2023Ingår i: Research on Aging, ISSN 0164-0275, E-ISSN 1552-7573, Vol. 45, nr 3-4, s. 385-395Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Policies and services to support informal caregivers vary considerably across countries. This paper examines the role of caregivers and how perspectives on that role may influence the availability of benefits and services in three countries that differ considerably in their care systems - Sweden, Ireland and the United States. We developed a nine-dimensional framework for examining differences, including policies and how the role of caregiver is conceptualized. We found differences in the three countries in how services are organized, which reflected assumptions about the caregiver role. There were also similarities in the three countries. Caregivers held an ambiguous position within each social system and there was little concern for equity in the delivery of support services. Increased clarity about the role of caregivers may facilitate development of policies that more effectively meet their varied needs.

  • 229.
    Calderón-Larrañaga, Amaia
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Hu, Xiaonan
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Guo, Jie
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Ferrucci, Luigi
    Xu, Weili
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Vetrano, Davide L.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Body mass trajectories and multimorbidity in old age: 12-year results from a population-based study2021Ingår i: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, Vol. 40, nr 12, s. 5764-5770Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background & aims: Body weight changes reflect and impact several health conditions in older age, but little is known about its relationship with multimorbidity. We aimed to study the association of long-terms trajectories of body mass index (BMI) with contemporaneous changes in multimorbidity −and multimorbidity type− development in a population-based cohort of older adults.

    Methods: Twelve-year BMI trajectories (2001–2013) were identified in subjects aged 60+ years from the Swedish National Study on Aging and Care in Kungsholmen (SNAC-K) using growth mixture models (N = 2189). Information on 60 chronic diseases and multimorbidity was ascertained based on clinical examinations, lab tests, medications, and inpatient and outpatient medical records. Linear mixed models were used to study the association between BMI trajectories and the speed of chronic disease accumulation, in general and by groups of cardiovascular and neuropsychiatric diseases.

    Results: Eighty percent of the study population was included in what we defined a stable BMI trajectory, 18% in a slow-decline trajectory with an accelerated BMI decline from age 78 onwards, and 2% in a fast-decline trajectory that reached underweight values before age 85. A significantly higher yearly rate of chronic disease accumulation was observed in the fast-decline versus stable trajectory (β = 0.221, 95% CI 0.090–0.352) after adjusting the model for age cohort, sex, education and time to death. Subjects in the slow-decline trajectory showed a significantly higher yearly rate of cardiovascular disease accumulation (β = 0.016, 95% CI 0.000–0.031); those in the fast-decline trajectory showed a faster accumulation of both cardiovascular (β = 0.020, 95% CI -0.025, 0.064) and neuropsychiatric diseases (β = 0.102, 95% CI 0.064–0.139), even if the former association did not reach statistical significance.

    Conclusion: Our results provide further evidence of the importance of carefully monitoring older adults with sustained weight loss, which is an early indicator of accelerated health deterioration, reflected in our study by a faster accumulation of chronic −especially neuropsychiatric− diseases.

  • 230.
    Calderón-Larrañaga, Amaia
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Santoni, Giola
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Wang, Hui Xin
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). Stockholms universitet, Samhällsvetenskapliga fakulteten, Stressforskningsinstitutet.
    Welmer, Anna-Karin
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Rizzuto, Debora
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Vetrano, Davide L.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). University of Rome, Italy.
    Marengoni, Alessandra
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). University of Brescia, Italy.
    Fratiglioni, Laura
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). Stockholm Gerontology Research Center, Sweden.
    Rapidly developing multimorbidity and disability in older adults: does social background matter?2018Ingår i: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 283, nr 5, s. 489-499Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background. Multimorbidity is among the most disabling geriatric conditions. In this study, we explored whether a rapid development of multi morbidity potentiates its impact on the functional independence of older adults, and whether different sociodemographic factors play a role beyond the rate of chronic disease accumulation. Methods. A random sample of persons aged >= 60 years (n = 2387) from the Swedish National study on Aging and Care in Kungsholmen (SNAC-K) was followed over 6 years. The speed of multimorbidity development was estimated as the rate of chronic disease accumulation (linear mixed models) and further dichotomized into the upper versus the three lower rate quartiles. Binomial negative mixed models were used to analyse the association between speed of multimorbidity development and disability (impaired basic and instrumental activities of daily living), expressed as the incidence rate ratio (IRR). The effect of sociodemographic factors, including sex, education, occupation and social network, was investigated. Results. The risk of new activity impairment was higher among participants who developed multi morbidity faster (IRR 2.4, 95% Cl 1.9-3.1) compared with those who accumulated diseases more slowly overtime, even after considering the baseline number of chronic conditions. Only female sex (IRR for women vs. men 1.6, 95% Cl 1.2-2.0) and social network (IRR for poor vs. rich social network 1.7, 95% Cl 1.3-2.2) showed an effect on disability beyond the rate of chronic disease accumulation. Conclusions. Rapidly developing multimorbidity is a negative prognostic factor for disability. However, sociodemographic factors such as sex and social network may determine older adults' reserves of functional ability, helping them to live independently despite the rapid accumulation of chronic conditions.

  • 231.
    Calderón-Larrañaga, Amaia
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Vetrano, Davide L.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). Catholic University of the Sacred Heart, Italy; Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Italy.
    Ferrucci, L.
    Mercer, S. W.
    Marengoni, A.
    Onder, G.
    Eriksdotter, M.
    Fratiglioni, Laura
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). Stockholm Gerontology Research Center, Sweden.
    Multimorbidity and functional impairment-bidirectional interplay, synergistic effects and common pathways2019Ingår i: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 285, nr 3, s. 255-271Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    This review discusses the interplay between multimorbidity (i.e. co-occurrence of more than one chronic health condition in an individual) and functional impairment (i.e. limitations in mobility, strength or cognition that may eventually hamper a person's ability to perform everyday tasks). On the one hand, diseases belonging to common patterns of multimorbidity may interact, curtailing compensatory mechanisms and resulting in physical and cognitive decline. On the other hand, physical and cognitive impairment impact the severity and burden of multimorbidity, contributing to the establishment of a vicious circle. The circle may be further exacerbated by people's reduced ability to cope with treatment and care burden and physicians' fragmented view of health problems, which cause suboptimal use of health services and reduced quality of life and survival. Thus, the synergistic effects of medical diagnoses and functional status in adults, particularly older adults, emerge as central to assessing their health and care needs. Furthermore, common pathways seem to underlie multimorbidity, functional impairment and their interplay. For example, older age, obesity, involuntary weight loss and sedentarism can accelerate damage accumulation in organs and physiological systems by fostering inflammatory status. Inappropriate use or overuse of specific medications and drug-drug and drug-disease interactions also contribute to the bidirectional association between multimorbidity and functional impairment. Additionally, psychosocial factors such as low socioeconomic status and the direct or indirect effects of negative life events, weak social networks and an external locus of control may underlie the complex interactions between multimorbidity, functional decline and negative outcomes. Identifying modifiable risk factors and pathways common to multimorbidity and functional impairment could aid in the design of interventions to delay, prevent or alleviate age-related health deterioration; this review provides an overview of knowledge gaps and future directions.

  • 232.
    Calderón-Larrañaga, Amaia
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). Aragon Health Sciences Institute (IACS), Spain.
    Vetrano, Davide L.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). Catholic University of Rome, Italy.
    Onder, Graziano
    Gimeno-Feliu, Luis A.
    Coscollar-Santaliestra, Carlos
    Carfí, Angelo
    Pisciotta, Maria S.
    Angleman, Sara
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Melis, René J. F.
    Santoni, Giola
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Mangialasche, Francesca
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Rizzuto, Debora
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Welmer, Anna-Karin
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Bernabei, Roberto
    Prados-Torres, Alexandra
    Marengoni, Alessandra
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). University of Brescia, Italy.
    Fratiglioni, Laura
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). Stockholm Gerontology Research Center, Sweden.
    Assessing and Measuring Chronic Multimorbidity in the Older Population: A Proposal for Its Operationalization2017Ingår i: The journals of gerontology. Series A, Biological sciences and medical sciences, ISSN 1079-5006, E-ISSN 1758-535X, Vol. 72, nr 10, s. 1417-1423Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background

    Although the definition of multimorbidity as the simultaneous presence of two or more chronic diseases is well established, its operationalization is not yet agreed. This study aims to provide a clinically driven comprehensive list of chronic conditions to be included when measuring multimorbidity.

    Methods

    Based on a consensus definition of chronic disease, all four-digit level codes from the International Classification of Diseases, 10th revision (ICD-10) were classified as chronic or not by an international and multidisciplinary team. Chronic ICD-10 codes were subsequently grouped into broader categories according to clinical criteria. Last, we showed proof of concept by applying the classification to older adults from the Swedish National study of Aging and Care in Kungsholmen (SNAC-K) using also inpatient data from the Swedish National Patient Register.

    Results

    A disease or condition was considered to be chronic if it had a prolonged duration and either (a) left residual disability or worsening quality of life or (b) required a long period of care, treatment, or rehabilitation. After applying this definition in relation to populations of older adults, 918 chronic ICD-10 codes were identified and grouped into 60 chronic disease categories. In SNAC-K, 88.6% had >= 2 of these 60 disease categories, 73.2% had >= 3, and 55.8% had >= 4.

    Conclusions

    This operational measure of multimorbidity, which can be implemented using either or both clinical and administrative data, may facilitate its monitoring and international comparison. Once validated, it may enable the advancement and evolution of conceptual and theoretical aspects of multimorbidity that will eventually lead to better care.

  • 233.
    Campbell, John
    et al.
    Tokyo University, Japan ; University of Michigan, USA.
    Ikegami, Naoki
    Keio University, Japan.
    Gori, Cristiano
    London School of Economics, UK ; Catholic University of Milan, Italy.
    Barbabella, Francesco
    National Institute of Health and Science on Ageing (INRCA), Italy.
    D'Amico, Francesco
    London School of Economics, UK.
    Holder, Holly
    The Nuffield Trust, UK.
    Ishibashi, Tomoaki
    Dia Foundation for Research on Ageing Societies, Japan.
    Johansson, Lennarth
    Jönköping University.
    Komisar, Harriet
    AARP’s Public Policy Institute, USA.
    Ring, Magnus
    Lund University.
    Theobald, Hildegard
    University of Vechta, Germany.
    How different countries allocate long-term care resources to older users: a comparative snapshot2016Ingår i: Long-term care reforms in OECD countries: Successes and failures / [ed] Cristiano Gori, José-Luis Fernandez, Raphael Wittenberg, Bristol: Policy Press, 2016, s. 47-76Kapitel i bok, del av antologi (Refereegranskat)
  • 234.
    Campbell, Sarah
    et al.
    Manchester Metropolitan University, Manchester, UK.
    Clark, Andrew
    University of Salford, Salford, UK.
    Keady, John
    University of Manchester, Manchester, UK.
    Manji, Kainde
    Age Scotland, Scotland, UK.
    Odzakovic, Elzana
    Jönköping University, Hälsohögskolan, HHJ, Avdelningen för omvårdnad. Jönköping University, Hälsohögskolan, HHJ. ADULT. Jönköping University, Hälsohögskolan, The Jönköping Academy for Improvement of Health and Welfare.
    Rummery, Kirstein
    University of Stirling, Stirling, UK.
    Ward, Richard
    University of Stirling, Stirling, UK.
    'I can see what's going on without being nosey…': What matters to people living with dementia about home as revealed through visual home tours.2023Ingår i: International Journal of Geriatric Psychiatry, ISSN 0885-6230, E-ISSN 1099-1166, Vol. 38, nr 9, artikel-id e5999Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    OBJECTIVES: This paper considers home from the perspective of people living with dementia supporting ongoing discourse around ageing in place and the significance of creating more inclusive communities.

    METHODS: Forty-six home tour interviews led by people living with dementia were conducted in England and Scotland to better understand the connectivity between home and neighbourhood for people living with dementia. These interviews used a range of participatory and creative approaches including video, photographic images and in situ interviews. Data were analysed via reflexive thematic analysis.

    RESULTS: Three themes were identified in data analysis. 1. Connected home and neighbourhood, where participants revealed the dynamic relationship between home and neighbourhood; 2. Practices of home, where participants discussed the everyday nature of their homes and routines; and 3. Displaying home and family, which reflected participant's biographical homes in the context of living with dementia.

    DISCUSSION: The findings show that home holds multiple meanings for people living with dementia. For example, home is understood as a part of the neighbourhood and an extension of the home space into gardens and backyards, thus extending existing discourses that solely focus on the inside of people's homes. For people living with dementia, homes are also sites of negotiation and renegotiation where new meanings are created to reflect the changing nature and context of the home. There is not one fixed solution to these issues. Support and understanding for people living with dementia will need to evolve to adapt to the shifting dynamics and multiple meanings of home.

  • 235.
    Canevelli, Marco
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). Sapienza University, Italy.
    Wallace, Lindsay M. K.
    Bruno, Giuseppe
    Cesari, Matteo
    Rockwood, Kenneth
    Ward, David D.
    Frailty is associated with the clinical expression of neuropsychological deficits in older adults2024Ingår i: European Journal of Neurology, ISSN 1351-5101, E-ISSN 1468-1331, Vol. 31, nr 1, artikel-id e16072Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background and purpose: The aim was to determine whether frailty is associated with the relationship between neuropsychological markers and global cognition in older adults.

    Methods: Cross-sectional analyzes were conducted of baseline data from three large cohort studies: National Alzheimer's Coordinating Center (NACC), Rush Memory and Aging Project (MAP) and Alzheimer's Disease Neuroimaging Initiative (ADNI). Studies recruited North American participants along the spectrum of cognitive functioning (44% no cognitive impairment at baseline). A frailty index was computed in each dataset. Frailty indices, neuropsychological tests (including measures of processing speed, episodic, semantic and working memory) and Mini-Mental State Examination (MMSE) scores were the variables of interest, with age, sex, education and apolipoprotein E ε4 evaluated as confounders.

    Results: Across all studies, 23,819 participants aged 55–104 (57% female) were included in analyzes. Frailty index scores were significantly and inversely associated with MMSE scores and significantly moderated relationships between neuropsychological test scores and MMSE scores. In participants with higher frailty index scores, lower neuropsychological test scores were more strongly associated with lower MMSE scores (standardized interaction coefficients ranged from −0.19 to −1.17 in NACC, −0.03 to −2.27 in MAP and −0.04 to −0.38 in ADNI, depending on the neuropsychological test). These associations were consistent across the different databases and were mostly independent of the composition of frailty indices (i.e., after excluding possible symptoms of dementia).

    Conclusions: Amongst older Americans, frailty is associated with the cognitive expression of neuropsychological deficits. Implementation of frailty assessment in routine neurological and neuropsychological practice should be considered to optimize care outcomes for older adults.

  • 236.
    Cao, Yang
    et al.
    Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län. Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
    Xiao, Zhenxu
    Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; National Center for Neurological Disorders, Shanghai, China.
    Wu, Wanqing
    Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; National Center for Neurological Disorders, Shanghai, China.
    Zhao, Qianhua
    Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; National Center for Neurological Disorders, Shanghai, China.
    Ding, Ding
    Institute of Neurology, Huashan Hospital, Fudan University, Shanghai, China; National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China; National Center for Neurological Disorders, Shanghai, China.
    Is Olfactory Impairment Associated With 10-year Mortality Mediating by Neurodegenerative Diseases in Older Adults? The Four-Way Decomposition Analysis2021Ingår i: Frontiers In Public Health, ISSN 2296-2565, Vol. 9, artikel-id 771584Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Literature shows that olfactory impairment (OI) is associated not only with neurodegenerative diseases (NDDs), but also with increased mortality. In this study, we analyzed data collected from the prospective phase of the 10-year follow-up of the Shanghai Aging Study (SAS) to explore the mediation effect of NDDs on the OI-mortality relationship.

    Methods: We analyzed data collected from the prospective phase of the 10-year follow-up of the SAS. We included 1,811 participants aged 60 years or older who completed both an olfactory identification test and a cognitive assessment at baseline (2010-2011). Survival status of the participants from baseline to December 31, 2019 was obtained from the local mortality surveillance system. We used the four-way decomposition method to attribute effects to interaction and mediation and to explore the mediation effect of NDDs on the OI-mortality relationship.

    Results: The four-way decomposition method revealed a statistically significant association of OI with death. Overall, 43% higher risk for death was associated with OI [excess relative risk (ERR) = 0.43, 95% CI: 0.06-0.80, p = 0.023]. Excluding the mediation from NDDs and interaction between OI and NDDs, the controlled direct effect of OI on death was even higher in NDDs participants, with an ERR of 77% (95% CI: 0.00-1.55, p = 0.050). Statistically significant association was found for failure to identify coffee (ERR = 0.77, 95% CI: 0.18-1.36, p = 0.010) and marginally significant associations were found for failure to identify cinnamon (ERR = 0.33, 95% CI: -0.02-0.68, p = 0.068) and rose (ERR = 0.33, 95% CI: -0.01-0.67, p = 0.054) with death.

    Conclusion: OI was associated with the long-term mortality in older adults and the association was even stronger in those with NDDs. Failure to identify coffee or rose was associated with a higher mortality risk, and the association was mediated by NDDs.

  • 237. Carfi, Angelo
    et al.
    Romano, Allegra
    Zaccaria, Giulia
    Villani, Emanuele Rocco
    Manes Gravina, Ester
    Vetrano, Davide Liborio
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). Università Cattolica del Sacro Cuore, Italy.
    Bernabei, Roberto
    Onder, Graziano
    The burden of chronic disease, multimorbidity, and polypharmacy in adults with Down syndrome2020Ingår i: American Journal of Medical Genetics. Part A, ISSN 1552-4825, E-ISSN 1552-4833, Vol. 182, nr 7, s. 1735-1743Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Data on clinical characteristics of adults with Down syndrome (DS) are limited and the clinical phenotype of these persons is poorly described. This study aimed to describe the occurrence of chronic diseases and pattern of medication use in a population of adults with DS. Participants were 421 community dwelling adults with DS, aged 18 years or older. Individuals were assessed through a standardized clinical protocol. Multimorbidity was defined as the occurrence of two or more chronic conditions and polypharmacy as the concomitant use of five or more medications. The mean age of study participants was 38.3 +/- 12.8 years and 214 (51%) were women. Three hundred and seventy-four participants (88.8%) presented with multimorbidity. The most prevalent condition was visual impairment (72.9%), followed by thyroid disease (50.1%) and hearing impairment (26.8%). Chronic diseases were more prevalent among participants aged >40 years. The mean number of medications used was 2.09 and polypharmacy was observed in 10.5% of the study sample. Psychotropic medications were used by a mean of 0.7 individuals of the total sample. The high prevalence of multimorbidity and the common use of multiple medications contributes to a high level of clinical complexity, which appears to be similar to the degree of complexity of the older non-trisomic population. A comprehensive and holistic approach, commonly adopted in geriatric medicine, may provide the most appropriate care to persons with DS as they grow into adulthood.

  • 238.
    Carlsson, Katarina Steen
    et al.
    Swedish Inst Hlth Econ, Sweden; Lund Univ, Sweden.
    Winding, Bent
    Swedish Orphan Biovitrum AB, Sweden.
    Astermark, Jan
    Skane Univ Hosp, Sweden.
    Baghaei, Fariba
    Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden.
    Brodin, Elisabeth
    Sahlgrens Univ Hosp, Sweden; Univ Gothenburg, Sweden.
    Funding, Eva
    Rigshosp, Denmark; Univ Copenhagen, Denmark.
    Holmström, Margareta
    Linköpings universitet, Institutionen för hälsa, medicin och vård, Avdelningen för diagnostik och specialistmedicin. Linköpings universitet, Medicinska fakulteten. Region Östergötland, Närsjukvården i centrala Östergötland, Medicinska och geriatriska akutkliniken. Karolinska Univ Hosp, Sweden.
    Osterholm, Klaus
    Helsinki Univ Hosp, Finland.
    Bergenstrale, Sofia
    Swedish Orphan Biovitrum AB, Sweden.
    Lethagen, Stefan
    Swedish Orphan Biovitrum AB, Sweden.
    High use of pain, depression, and anxiety drugs in hemophilia: more than 3000 people with hemophilia in an 11-year Nordic registry study2023Ingår i: RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS, ISSN 2475-0379, Vol. 7, nr 2, artikel-id e100061Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Pain is a common feature of hemophilia, but prevalence of depression and anxiety is less studied. Registry data on prescription drugs can provide an objective measure of the magnitude of these complications.Objectives: To identify treatment patterns of prescribed pain, antidepressant, and antianxiety medications compared with those of matched controls in 4 Nordic countries.Methods: The MIND study (NCT03276130) analyzed longitudinal individual-level national data during 2007-2017. People with hemophilia (PwH) were identified from National Health Data Registers by diagnosis or factor replacement treatment and compared with population controls. Three subgroups were defined by the use of factor concentrates and sex (moderate-to-high factor consumption (factor VIII [FVIII] use of =40 IU/kg/week or FIX use of =10 IU/kg/week), low factor consumption, and women including carriers).Results: Data of 3246 PwH, representing 30,184 person-years, were analyzed. PwH (including children and adults) used more pain, depression, and anxiety medications compared with controls. This was most accentuated in the moderate-to-high factor consumption group and notably also observed in men with low factor consumption and women including carriers, usually representing a milder phenotype. A higher opioid use was observed across all age groups: 4-to 6-fold higher in the moderate-to-high factor consumption group and 2-to 4-fold higher in the low factor consumption group.Conclusion: The consistent higher use of pain, depression, and anxiety medications among PwH compared with population controls, regardless of age, sex, or factor consumption, in broad national data suggests a need for improved bleed protection and hemophilia care for all severities including mild hemophilia.

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  • 239. Carretero, Stephanie
    et al.
    Stewart, James
    Centeno, Clara
    Barbabella, Francesco
    Schmidt, Andrea
    Lamontagne-Godwin, Frédérique
    Lamura, Giovanni
    Can Technology-based Services support Long-term Care Challenges in Home Care?: Analysis of evidence from social innovation good practices across the EU : CARICT project summary report2012Bok (Övrig (populärvetenskap, debatt, mm))
    Abstract [en]

    Deployment and use of technological services for informal carers is still limited, mainly due to users' low digital skills, the lack of demonstrated business cases, and the poor evidence of the impact and sustainability of these services. The CARICT project aimed to collect evidence-based results on the impact of ICT-enabled domiciliary care services, and to make policy recommendations to develop, scale and replicate them in the European Union. The methodology was based on a mapping of 52 ICT-based services for informal carers developed in Europe, and a cross–analysis of 12 of these initiatives to get data on their impacts, drivers, business models, success factors, and challenges. The main results show that there is a wide range of successful, not very costly and beneficial examples of ICT-based support for carers across Europe. The cross-analysis indicated that these services had positive impacts on the quality of life of elderly people and informal carers, the quality of care and the financial sustainability of the health and social systems. The data also confirm that policy at European, national, regional and local levels can promote the successful development, implementation and transferability of these services through funding, policy leadership and by promoting stronger cooperation among stakeholders including end-users, mainly from the third sector and informal carers, to create a new value chain in the provision of long-term care. These findings help to achieve the objectives of European policy defined by the 2020 Strategy, and more specifically the Digital Agenda for Europe (DAE) and the European Innovation Partnership on Healthy and Active Ageing (EIP AHA)

  • 240.
    Carretero, Stephanie
    et al.
    Institute for Prospective Technological Studies (IPTS), Spain.
    Stewart, James
    Institute for Prospective Technological Studies (IPTS), Spain.
    Centeno, Clara
    Institute for Prospective Technological Studies (IPTS), Spain.
    Barbabella, Francesco
    European Centre for Social Welfare Policy and Research, Austria.
    Schmidt, Andrea
    European Centre for Social Welfare Policy and Research, Austria.
    Lamontagne-Godwin, Frédérique
    European Centre for Social Welfare Policy and Research, Austria.
    Lamura, Giovanni
    European Centre for Social Welfare Policy and Research, Austria.
    Can Technology-based Services support Long-term Care Challenges in Home Care?: Analysis of Evidence from Social Innovation Good Practices across the EU: CARICT Project Summary Report2012Rapport (Övrig (populärvetenskap, debatt, mm))
    Abstract [en]

    Deployment and use of technological services for informal carers is still limited, mainly due to users' low digital skills, the lack of demonstrated business cases, and the poor evidence of the impact and sustainability of these services. The CARICT project aimed to collect evidence-based results on the impact of ICT-enabled domiciliary care services, and to make policy recommendations to develop, scale and replicate them in the European Union. The methodology was based on a mapping of 52 ICT-based services for informal carers developed in Europe, and a cross–analysis of 12 of these initiatives to get data on their impacts, drivers, business models, success factors, and challenges. The main results show that there is a wide range of successful, not very costly and beneficial examples of ICT-based support for carers across Europe. The cross-analysis indicated that these services had positive impacts on the quality of life of elderly people and informal carers, the quality of care and the financial sustainability of the health and social systems. The data also confirm that policy at European, national, regional and local levels can promote the successful development, implementation and transferability of these services through funding, policy leadership and by promoting stronger cooperation among stakeholders including end-users, mainly from the third sector and informal carers, to create a new value chain in the provision of long-term care. These findings help to achieve the objectives of European policy defined by the 2020 Strategy, and more specifically the Digital Agenda for Europe (DAE) and the European Innovation Partnership on Healthy and Active Ageing (EIP AHA)

  • 241.
    Castiglione, Alessandro
    et al.
    Department of Neurosciences, University of Padua, Padua, Italy; Complex Operative Unit of Otolaryngology, Hospital of Padua, Padua, Italy.
    Casa, Mariella
    Regional Center for the Study and Treatment of the Aging Brain, Department of Internal Medicine, Padua, Italy.
    Gallo, Samanta
    Complex Operative Unit of Otolaryngology, Hospital of Padua, Padua, Italy.
    Sorrentino, Flavia
    Complex Operative Unit of Otolaryngology, Hospital of Padua, Padua, Italy.
    Dhima, Sonila
    Complex Operative Unit of Otolaryngology, Hospital of Padua, Padua, Italy.
    Cilia, Dalila
    Department of Neurosciences, University of Padua, Padua, Italy.
    Lovo, Elisa
    Department of Neurosciences, University of Padua, Padua, Italy.
    Gambin, Marta
    Department of Neurosciences, University of Padua, Padua, Italy.
    Previato, Maela
    Department of Neurosciences, University of Padua, Padua, Italy.
    Colombo, Simone
    Department of Neurosciences, University of Padua, Padua, Italy.
    Caserta, Ezio
    Complex Operative Unit of Otolaryngology, Hospital of Padua, Padua, Italy.
    Gheller, Flavia
    Department of Neurosciences, University of Padua, Padua, Italy.
    Giacomelli, Cristina
    Department of Neurosciences, University of Padua, Padua, Italy.
    Montino, Silvia
    Department of Neurosciences, University of Padua, Padua, Italy.
    Limongi, Federica
    Institute of Neuroscience, National Research Council, Padua, Italy.
    Brotto, Davide
    Complex Operative Unit of Otolaryngology, Hospital of Padua, Padua, Italy.
    Gabelli, Carlo
    Regional Center for the Study and Treatment of the Aging Brain, Department of Internal Medicine, Padua, Italy.
    Trevisi, Patrizia
    Department of Neurosciences, University of Padua, Padua, Italy; Complex Operative Unit of Otolaryngology, Hospital of Padua, Padua, Italy.
    Bovo, Roberto
    Department of Neurosciences, University of Padua, Padua, Italy; Complex Operative Unit of Otolaryngology, Hospital of Padua, Padua, Italy.
    Martini, Alessandro
    Department of Neurosciences, University of Padua, Padua, Italy; Complex Operative Unit of Otolaryngology, Hospital of Padua, Padua, Italy.
    Correspondence Between Cognitive and Audiological Evaluations Among the Elderly: A Preliminary Report of an Audiological Screening Model of Subjects at Risk of Cognitive Decline With Slightto Moderate Hearing Loss2019Ingår i: Frontiers in Neuroscience, ISSN 1662-4548, E-ISSN 1662-453X, Vol. 13, artikel-id 1279Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Epidemiological studies show increasing prevalence rates of cognitive decline and hearing loss with age, particularly after the age of 65 years. These conditions are reported to be associated, although conclusive evidence of causality and implications is lacking. Nevertheless, audiological and cognitive assessment among elderly people is a key target for comprehensive and multidisciplinary evaluation of the subject's frailty status. To evaluate the use of tools for identifying older adults at risk of hearing loss and cognitive decline and to compare skills and abilities in terms of hearing and cognitive performances between older adults and young subjects, we performed a prospective cross-sectional study using supraliminal auditory tests. The relationship between cognitive assessment results and audiometric results was investigated, and reference ranges for different ages or stages of disease were determined. Patients older than 65 years with different degrees of hearing function were enrolled. Each subject underwent an extensive audiological assessment, including tonal and speech audiometry, Italian Matrix Sentence Test, and speech audiometry with logatomes in quiet. Cognitive function was screened and then verified by experienced clinicians using the Montreal Cognitive Assessment Score, the Geriatric Depression Scale, and further investigations in some. One hundred twenty-three subjects were finally enrolled during 2016-2019: 103 were >65 years of age and 20 were younger participants (as controls). Cognitive functions showed a correlation with the audiological results in post-lingual hearing-impaired patients, in particular in those affected by slight to moderate hearing loss and aged more than 70 years. Audiological testing can thus be useful in clinical assessment and identification of patients at risk of cognitive impairment. The study was limited by its sample size (CI 95%; CL 10%), strict dependence on language, and hearing threshold. Further investigations should be cond

  • 242.
    Cavazzana, Annachiara
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen. TU Dresden, Germany.
    Röhrborn, Anja
    Garthus-Niegel, Susan
    Larsson, Maria
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Psykologiska institutionen, Perception och psykofysik.
    Hummel, Thomas
    Croy, Ilona
    Sensory-specific impairment among older people: An investigation using both sensory thresholds and subjective measures across the five senses2018Ingår i: PLOS ONE, E-ISSN 1932-6203, Vol. 13, nr 8, artikel-id e0202969Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Age-related sensory impairment is a slow and gradual progress, which affects multiple modalities. Two contradictory hypotheses exist about the age-related decline of sensory thresholds. The common factor theory assumes one underlying factor-which accounts for the loss of several sensory modalities simultaneously-and the specific factor theory predicts that the sensory decline is uncorrelated between different modalities. In this study, we aimed to explore whether (i) there is a common factor of sensory thresholds in older people, (ii) older people assume that sensory decline in one modality also affects other modalities, (iii) there is a relation between sensory threshold and the subjective assessment of sensory function. This was accomplished by collecting both threshold measures and self-reported ratings for smell, hearing, taste, vision, and touch function in a group of 104 older people (mean age: 67.2 years; SD: 9.85; range: 50-100 years). Results indicated that there was no common factor of sensory thresholds, hence an impairment in one modality did not necessarily imply a shortfall in other modalities. In contrast, our results suggested one or two common factor(s) for the participants' ratings. Participants who reported a diminished function in one sense tended to generalize this rating to the other senses as well. The correspondence between subjective ratings and sensory thresholds was relatively good for vision and audition, although no correlations were observed for the other domains. These findings have implications for clinicians, suggesting that subjective measures should be combined with sensory threshold measurements when evaluating sensory dysfunction. Also, these data convey a positive message for older people and their physicians by showing that loss in one sensory modality does not necessarily generalize to losses across all sensory modalities.

  • 243.
    Cecchini, Valeria
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Agahi, Neda
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Does losing family members in midlife matter for late-life mental and cognitive health? A longitudinal study of older Swedes spanning 30 years2024Ingår i: Aging & Mental Health, ISSN 1360-7863, E-ISSN 1364-6915Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objectives: Mental and cognitive health is crucial to ensure well-being in older age. However, prolonged periods of stress, grief, and bereavement might compromise mental health balance, leading to profound changes. This study investigated the sex-stratified associations between midlife bereavement experiences (e.g. sibling loss, spousal loss, and multiple losses) and late-life depression (LLD) and cognitive impairment.

    Method: Linked data from the Swedish Level-of-Living Survey and the Swedish Panel Study of Living Conditions of the Oldest Old (SWEOLD) were used. Multiple logistic regressions were performed to examine the associations between midlife bereavement and LLD (n = 1078) and cognitive impairment (n = 995), separately.

    Results: Sibling loss and multiple losses in midlife were associated with lower odds of LLD, especially among women. Among men, sibling loss in midlife was associated with lower odds of cognitive impairment, while the experience of two losses among women suggested an increased (but non-significant) risk of cognitive impairment. Interaction analyses did not show significant effects between bereavement and gender on LLD and cognitive impairment.

    Conclusion: Midlife bereavement might have gendered implications on LLD and cognitive impairment, but associations need to be confirmed by well-powered studies. Further research is warranted to elucidate the association between multiple midlife losses and reduced LLD risk.

  • 244.
    Cedersund, Elisabet
    et al.
    Linköpings universitet, Institutionen för samhälls- och välfärdsstudier, Avdelningen Åldrande och social förändring. Linköpings universitet, Filosofiska fakulteten. Linköpings universitet, Institutionen för kultur och samhälle, Avdelningen för åldrande och social förändring.
    Olaison, Anna
    Linköpings universitet, Institutionen för kultur och samhälle, Avdelningen för socialt arbete. Linköpings universitet, Filosofiska fakulteten.
    Sverker, Annette M.
    Linköpings universitet, Institutionen för kultur och samhälle, Avdelningen för socialt arbete. Linköpings universitet, Filosofiska fakulteten.
    Finding the right care path: Experiences of participation in care by older persons with complex health problems: A Focused Primary Care Intervention2021Konferensbidrag (Refereegranskat)
    Abstract [en]

    Introduction: Despite evidence that older persons want to be involved in care, little is known about how older people with complex health problems living at home experience participation in care provided by different stakeholders. This study investigates the experiences of participation in care by older people, following their involvement in a proactive intervention based on a new health care model called Focused Primary Care. Material and methods: Individual semi-structured interviews were conducted with 20 older persons in five municipalities in Sweden. All the interviewees had participated in the intervention. Results: The older persons highlighted opportunities and limitations for participation on a personal level i.e. conditions for being involved in direct care and in relation to independence. Experiences of participation on an organisational level were reported to a lesser degree. In order to keep care contacts together and improve participation, a coordinating person (called “the spider in the net”) was requested who could safeguard the staff’s relationship with the older person. Conclusions: Primary care should to a greater extent involve older persons more directly in the planning and execution of care. There is considerable potential for developing the health and primary care sector to better target the needs of older persons with complex health problems, and to enhance their participation and independence. Interventions, like the one followed in this project, can play a critical role in realising the needs of older persons, where providing participation in care is recognised as a significant goal to assist them in navigating the care system. 

  • 245. Cesari, M.
    et al.
    Canevelli, Marco
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Italy.
    Calvani, R.
    Aprahamian, I.
    Inzitari, M.
    Marzetti, E.
    The Management of Frailty: Barking Up the Wrong Tree2022Ingår i: Journal of Frailty & Aging, ISSN 2260-1341, E-ISSN 2273-4309, Vol. 11, nr 2, s. 127-128Artikel i tidskrift (Övrigt vetenskapligt)
  • 246.
    Chang, Milan
    et al.
    Faculty of Health Promotion, Sports and Leisure Studies, School of Education, University of Iceland, Reykjavik, Iceland.
    Geirsdottir, Olof G.
    The Icelandic Gerontological Research Institute, National University Hospital of Iceland & Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
    Sigurdarsdottir, Sigurveig H.
    School of Social Science, University of Iceland, Reykjavik, Iceland.
    Kåreholt, Ingemar
    Jönköping University, Hälsohögskolan, HHJ, Institutet för gerontologi. Jönköping University, Hälsohögskolan, HHJ. ARN-J (Aging Research Network - Jönköping).
    Ramel, Alfons
    The Icelandic Gerontological Research Institute, National University Hospital of Iceland & Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
    Associations between education and need for care among community dwelling older adults in Iceland2019Ingår i: Scandinavian Journal of Caring Sciences, ISSN 0283-9318, E-ISSN 1471-6712, Vol. 33, nr 4, s. 885-891Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    BACKGROUND: Older adults in Iceland have good access to social services that support them in maintaining an independent life, although receiving informal care is common for community living older adults in Iceland. The aim of this study was to examine whether the need for care as well as receiving formal and informal care is associated with education among older adults in Iceland.

    METHODS: Among a national sample of 782 Icelandic community dwelling old adults (mean age 76.9 ± 7.4 years, 55% women), a telephone survey was conducted. The survey included questions on: socioeconomic status, social network, health status, activities of daily living and formal/informal care.

    RESULTS: A full data set was available for 720 subjects and among these, 349 (48.5%) had no need for care, 197 (27.4%) received informal care only, 31 (4.3%) received formal care only, and 143 (19.9%) received both type of care. Participants with higher education were significantly less likely to need care (OR 0.67, 95% CI, 0.47-0.97, p = 0.031) when compared with those who had primary education. Categorisation by age showed that this difference was only significant in participants younger than 80 years. Education was not related to formal care, but adults with higher education were less likely to receive informal care compared with older adults who had primary education (OR: 0.65, 95%CI: 0.46, 0.93, p = 0.018).

    CONCLUSIONS: People with higher education were significantly less likely to need care and this association was mainly present among those aged below 80 years. Further, in participants that needed care, the likelihood of receiving informal care was lower in highly educated participants, but no differences in formal care were observed between educational levels.

  • 247. Chen, Huashuai
    et al.
    Ye, Kaisy Xinhong
    Feng, Qiushi
    Cao, Kai
    Yu, Jintai
    Li, Chunbo
    Zhang, Can
    Yu, Lirong
    Maier, Andrea Britta
    Langa, Kenneth M.
    Qiu, Chengxuan
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Zeng, Yi
    Feng, Lei
    Trends in the prevalence of cognitive impairment at old age in China, 2002–20182024Ingår i: Alzheimer's & Dementia: Journal of the Alzheimer's Association, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 20, nr 2, s. 1387-1396Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    INTRODUCTION: China has the world's largest number of older adults with cognitive impairment (CI). We aimed to examine secular trends in the prevalence of CI in China from 2002 to 2018.

    METHODS: Generalized estimating equations (GEE) was used to assess changes in CI trend in 44,154 individuals (72,027 observations) aged 65 to 105 years old.

    RESULTS: The prevalence of CI increased from 2002 to 2008 and then decreased until 2018. The age-standardized prevalence increased from 25.7% in 2002, 26.1% in 2005, to 28.2% in 2008, then decreased to 26.0% in 2011, 25.3% in 2014, and 24.9% in 2018. Females and those ≥ 80 years old had greater CI prevalence.

    DISCUSSION: The prevalence of CI showed an inverted U shape from early 2000s to late 2010s with a peak in 2008. Follow-up studies are needed to confirm the decreasing trend after 2008 and examine the contributing factors and underlying mechanisms of this trend.

  • 248. Chen, Hui
    et al.
    Cao, Yaying
    Ma, Yuan
    Xu, Weili
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). Tianjin Medical University, China.
    Zong, Geng
    Yuan, Changzheng
    Age- and sex-specific modifiable risk factor profiles of dementia: evidence from the UK Biobank2023Ingår i: European Journal of Epidemiology, ISSN 0393-2990, E-ISSN 1573-7284, Vol. 38, nr 1, s. 83-93Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Dementia constitutes a worldwide concern. To characterize the age- and sex-specific modifiable risk factor profiles of dementia, we included 497,401 UK Biobank participants (mean age = 56.5 years) without dementia at baseline (2006–2010) and followed them until March 2021. Cox proportional hazard models were used to estimate the age- and sex-specific hazard ratios (HRs) of incident dementia associated with socioeconomic (less education and high Townsend deprivation index), lifestyle (non-moderate alcohol intake, current smoking, suboptimal diet, physical inactivity, and unhealthy sleep duration), and health condition factors (hypertension, diabetes, cardiovascular diseases, and depressive symptoms). We also calculated the population attributable fractions (PAFs) of these factors. During follow-up (mean = 11.6 years), we identified 6564 dementia cases. HRs for the risk factors were similar between the sexes, while most factors showed stronger associations among younger participants. For example, the HRs of smoking were 1.74 (95% CI: 1.23, 2.47) for individuals aged < 50 years, and 1.18 (1.05, 1.33) for those aged ≥ 65 years. Overall, 46.8% (37.4%, 55.2%) of dementia cases were attributable to the investigated risk factors. The PAFs of the investigated risk factors also decreased with age, but that for health condition risk factors decreased with lower magnitude than socioeconomic and lifestyle risk factors. The stronger associations and greater PAFs of several modifiable risk factors for dementia among younger adults than older participants underscored the importance of dementia prevention from an earlier stage across the adult life course. 

  • 249. Chen, Hui
    et al.
    Dunk, Michelle M.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Wang, Binghan
    Zhao, Mengjia
    Shen, Jie
    Zong, Geng
    Pan, Yuesong
    Tong, Lusha
    Xu, Weili
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Yuan, Changzheng
    Associations of the Mediterranean-DASH Intervention for Neurodegenerative Delay diet with brain structural markers and their changes2024Ingår i: Alzheimer's & Dementia: Journal of the Alzheimer's Association, ISSN 1552-5260, E-ISSN 1552-5279, Vol. 20, nr 2, s. 1190-1200Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    INTRODUCTION: The associations of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet with brain structural changes are unclear.

    METHODS: Among 26,466 UK Biobank participants, a 15-point MIND score was calculated from 24-hour diet recalls from 2009 to 2012. We assessed its associations with 17 magnetic-resonance-derived brain volumetric markers and their longitudinal changes and explored whether genetic factors modify the associations.

    RESULTS: Higher MIND adherence was associated with larger volumes of thalamus, putamen, pallidum, hippocampus, and accumbens (beta per 3-unit increment ranging from 0.024 to 0.033) and lower white matter hyperintensities (P-trends < 0.05), regardless of genetic predispositions of Alzheimer's disease. MIND score was not associated with their longitudinal changes (P > 0.05) over a median of 2.2 years among participants with repeated imaging assessments (N = 2963), but was associated with slower atrophy in putamen (beta: 0.026, P-trend = 0.044) and pallidum (beta: 0.030, P-trend = 0.033) among APOE ε4 non-carriers (N = 654).

    DISCUSSION: The MIND diet showed beneficial associations with certain brain imaging markers, and its associations with long-term brain structural changes warrants future investigation.

  • 250.
    Chen, Shuyun
    et al.
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Calderón-Larrañaga, Amaia
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Saadeh, Marguerita
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Dohrn, Ing-Mari
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI).
    Welmer, Anna-Karin
    Stockholms universitet, Samhällsvetenskapliga fakulteten, Centrum för forskning om äldre och åldrande (ARC), (tills m KI). Stockholm Gerontology Research Center, Sweden.
    Correlations of Subjective and Social Well-Being With Sedentary Behavior and Physical Activity in Older Adults—A Population-Based Study 2021Ingår i: The journals of gerontology. Series A, Biological sciences and medical sciences, ISSN 1079-5006, E-ISSN 1758-535X, Vol. 76, nr 10, s. 1789-1795Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Background: Subjective and social well-being, avoiding sedentary behavior (SB), and engaging in physical activity (PA) are important factors for health in older adults, but the extent to which they are related to each other remains unclear. We aimed to investigate these correlations, and whether they differ by age.

    Method: A cross-sectional study was carried out in 595 people aged 66 years and older, from the Swedish National study on Aging and Care in Kungsholmen. Subjective and social well-being (life satisfaction, positive and negative affect, social connections, social support, and social participation) were assessed through validated questionnaires and activPAL3 accelerometers provided information on SB and PA. Data were analyzed using multi-adjusted quantile regression models.

    Results: Higher positive affect was significantly associated with less daily sitting time (β = −27.08, 95% confidence interval [CI]: −47.77, −6.39) and higher levels of light PA (LPA) (β = 40.67, 95% CI: 21.06, 60.28). Higher levels of social support and social participation were associated with less daily sitting time (β = −22.79, 95% CI: −39.97, −5.62; and β = −21.22, 95% CI: −39.99, −2.44) and more time in LPA (β = 23.86, 95% CI: 4.91, 42.81; and β = 25.37, 95% CI: 6.27, 44.47). Stratified analyses suggested that the associations of positive affect and social participation were strongest for individuals aged 80 years and older.

    Conclusions: Our results suggest that older adults with higher levels of subjective and social well-being spend less time sitting and engage more in PA. This was especially evident among the oldest-old individuals. Future research should longitudinally investigate the directionality of these correlations.

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