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Quality of Life and Kidney Function in Older Adults: Prospective Data of the SCOPE Study
Ben-Gurion University of the Negev, Beer-Sheva, Israel; Maccabi Health Services, Southern District, Omer, Israel.
Friedrich-Alexander-Universität Erlangen-Nürnberg, Nürnberg, Germany.
Italian National Research Center on Aging (IRCCS INRCA), Ancona, Italy.
Italian National Research Center on Aging (IRCCS INRCA), Ancona, Italy.
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2023 (Engelska)Ingår i: Journal of Clinical Medicine, E-ISSN 2077-0383, Vol. 12, nr 12, artikel-id 3959Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

A longitudinal alteration in health-related quality of life (HRQoL) over a two-year period and its association with early-stage chronic kidney disease (CKD) progression was investigated among 1748 older adults (>75 years). HRQoL was measured by the Euro-Quality of Life Visual Analog Scale (EQ-VAS) at baseline and at one and two years after recruitment. A full comprehensive geriatric assessment was performed, including sociodemographic and clinical characteristics, the Geriatric Depression Scale-Short Form (GDS-SF), Short Physical Performance Battery (SPPB), and estimated glomerular filtration rate (eGFR). The association between EQ-VAS decline and covariates was investigated by multivariable analyses. A total of 41% of the participants showed EQ-VAS decline, and 16.3% showed kidney function decline over the two-year follow-up period. Participants with EQ-VAS decline showed an increase in GDS-SF scores and a greater decline in SPPB scores. The logistic regression analyses showed no contribution of a decrease in kidney function on EQ-VAS decline in the early stages of CKD. However, older adults with a greater GDS-SF score were more likely to present EQ-VAS decline over time, whereas an increase in the SPPB scores was associated with less EQ-VAS decline. This finding should be considered in clinical practice and when HRQoL is used to evaluate health interventions among older adults.

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2023. Vol. 12, nr 12, artikel-id 3959
Nyckelord [en]
chronic kidney disease, cohort studies, disease progression, older adults, prospective studies, quality of life
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Geriatrik Gerontologi, medicinsk/hälsovetenskaplig inriktning
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URN: urn:nbn:se:du-46363DOI: 10.3390/jcm12123959ISI: 001017402300001PubMedID: 37373653Scopus ID: 2-s2.0-85163761660OAI: oai:DiVA.org:du-46363DiVA, id: diva2:1779317
Tillgänglig från: 2023-07-04 Skapad: 2023-07-04 Senast uppdaterad: 2023-08-04Bibliografiskt granskad

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