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Composite attenuation correction method using a 68Ge-transmission multi-atlas for quantitative brain PET/MR.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Radiologi.ORCID-id: 0000-0002-1498-1327
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper, Radiologi.
Vise andre og tillknytning
2022 (engelsk)Inngår i: Physica medica (Testo stampato), ISSN 1120-1797, E-ISSN 1724-191X, Vol. 97, s. 36-43, artikkel-id S1120-1797(22)01949-4Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

In positron emission tomography (PET), 68Ge-transmission scanning is considered the gold standard in attenuation correction (AC) though not available in current dual imaging systems. In this experimental study we evaluated a novel AC method for PET/magnetic resonance (MR) imaging which is essentially based on a composite database of multiple 68Ge-transmission maps and T1-weighted (T1w) MR image-pairs (composite transmission, CTR-AC). This proof-of-concept study used retrospectively a database with 125 pairs of co-registered 68Ge-AC maps and T1w MR images from anatomical normal subjects and a validation dataset comprising dynamic [11C]PE2I PET data from nine patients with Parkinsonism. CTR-AC maps were generated by non-rigid image registration of all database T1w MRI to each subject's T1w, applying the same transformation to every 68Ge-AC map, and averaging the resulting 68Ge-AC maps. [11C]PE2I PET images were reconstructed using CTR-AC and a patient-specific 68Ge-AC map as the reference standard. Standardized uptake values (SUV) and quantitative parameters of kinetic analysis were compared, i.e., relative delivery (R1) and non-displaceable binding potential (BPND). CTR-AC showed high accuracy for whole-brain SUV (mean %bias ± SD: 0.5 ± 3.5%), whole-brain R1 (-0.1 ± 3.2%), and putamen BPND (3.7 ± 8.1%). SUV and R1 precision (SD of %bias) were modest and lowest in the anterior cortex, with an R1 %bias of -1.1 ± 6.4%). The prototype CTR-AC is capable of providing accurate MRAC-maps with continuous linear attenuation coefficients though still experimental. The method's accuracy is comparable to the best MRAC methods published so far, both in SUV and as found for ZTE-AC in quantitative parameters of kinetic modelling.

sted, utgiver, år, opplag, sider
Elsevier BV Elsevier, 2022. Vol. 97, s. 36-43, artikkel-id S1120-1797(22)01949-4
Emneord [en]
(68)Ge-transmission scan, Attenuation correction, Hybrid imaging, Kinetic modelling, PET/MRI, [(11)C]PE2I
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-474156DOI: 10.1016/j.ejmp.2022.03.012ISI: 000790956600003PubMedID: 35339864OAI: oai:DiVA.org:uu-474156DiVA, id: diva2:1657113
Tilgjengelig fra: 2022-05-09 Laget: 2022-05-09 Sist oppdatert: 2024-01-15bibliografisk kontrollert

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Sousa, Joao M.Appel, LieuweNyholm, DagAhlström, HåkanLubberink, Mark
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